The HIV-1 Integrase C-Terminal Domain Induces TAR RNA Structural Changes Promoting Tat Binding

Recent evidence indicates that the HIV-1 Integrase (IN) binds the viral genomic RNA (gRNA), playing a critical role in the morphogenesis of the viral particle and in the stability of the gRNA once in the host cell. By combining biophysical, molecular biology, and biochemical approaches, we found tha...

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Detalles Bibliográficos
Autores principales: Rocchi, Cecilia, Louvat, Camille, Miele, Adriana Erica, Batisse, Julien, Guillon, Christophe, Ballut, Lionel, Lener, Daniela, Negroni, Matteo, Ruff, Marc, Gouet, Patrice, Fiorini, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692563/
https://www.ncbi.nlm.nih.gov/pubmed/36430221
http://dx.doi.org/10.3390/ijms232213742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692563/
https://www.ncbi.nlm.nih.gov/pubmed/36430221
http://dx.doi.org/10.3390/ijms232213742

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