Cargando…

Gαq Is the Specific Mediator of PAR-1 Transactivation of Kinase Receptors in Vascular Smooth Muscle Cells

Aims: G protein-coupled receptor (GPCR) transactivation of kinase receptors greatly expands the actions attributable to GPCRs. Thrombin, via its cognate GPCR, protease-activated receptor (PAR)-1, transactivates tyrosine and serine/threonine kinase receptors, specifically the epidermal growth factor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kamato, Danielle, Gabr, Mai, Kumarapperuma, Hirushi, Chia, Zheng J., Zheng, Wenhua, Xu, Suowen, Osman, Narin, Little, Peter J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692893/ https://www.ncbi.nlm.nih.gov/pubmed/36430902 http://dx.doi.org/10.3390/ijms232214425

Ejemplares similares

Lipopolysaccharide acting via toll-like receptor 4 transactivates the TGF-β receptor in vascular smooth muscle cells
por: Afroz, Rizwana, et al.
Publicado: (2022)

RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells
por: Kamato, Danielle, et al.
Publicado: (2017)

GPCR transactivation signalling in vascular smooth muscle cells: role of NADPH oxidases and reactive oxygen species
por: Mohamed, Raafat, et al.
Publicado: (2019)

Atherogenic, fibrotic and glucose utilising actions of glucokinase activators on vascular endothelium and smooth muscle
por: Al-aryahi, Sefaa, et al.
Publicado: (2014)

Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Gα(/q,11)
por: Kamato, Danielle, et al.
Publicado: (2015)

Multiple Growth Factors, But Not VEGF, Stimulate Glycosaminoglycan Hyperelongation in Retinal Choroidal Endothelial Cells
por: Al Gwairi, Othman, et al.
Publicado: (2016)

Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling
por: Zhou, Ying, et al.
Publicado: (2021)

Non-Mouse Models of Atherosclerosis: Approaches to Exploring the Translational Potential of New Therapies
por: Kamato, Danielle, et al.
Publicado: (2022)

Endothelial Dysfunction and Cardiovascular Disease: History and Analysis of the Clinical Utility of the Relationship
por: Little, Peter J., et al.
Publicado: (2021)

Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function
por: Deng, Mingying, et al.
Publicado: (2020)

The Paradigm of G Protein Receptor Transactivation: A Mechanistic Definition and Novel Example
por: Little, Peter J., et al.
Publicado: (2011)

Vascular calcification is coupled with phenotypic conversion of vascular smooth muscle cells through Klf5-mediated transactivation of the Runx2 promoter
por: Zhang, Jing, et al.
Publicado: (2014)

Impact of sodium glucose cotransporter 2 (SGLT2) inhibitors on atherosclerosis: from pharmacology to pre-clinical and clinical therapeutics
por: Liu, Zhenghong, et al.
Publicado: (2021)

GLP-1 receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential
por: Ma, Xiaoxuan, et al.
Publicado: (2021)

Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions
por: Little, Peter J, et al.
Publicado: (2007)

Low Levels of the Reverse Transactivator Fail to Induce Target Transgene Expression in Vascular Smooth Muscle Cells
por: Viceconte, Nikenza, et al.
Publicado: (2014)

Cellular and Molecular Pathology of Age-Related Macular Degeneration: Potential Role for Proteoglycans
por: Al Gwairi, Othman, et al.
Publicado: (2016)

Vascular wall proteoglycan synthesis and structure as a target for the prevention of atherosclerosis
por: Little, Peter J, et al.
Publicado: (2007)

Independent β-Arrestin2 and G(q)/Protein Kinase Cζ Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the Epidermal Growth Factor Receptor
por: Kim, Jihee, et al.
Publicado: (2009)

Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo
por: Ballinger, Mandy L, et al.
Publicado: (2010)

Phytanic acid activates NADPH oxidase through transactivation of epidermal growth factor receptor in vascular smooth muscle cells
por: Dhaunsi, Gursev S., et al.
Publicado: (2016)

Matrix metalloproteinase-2-induced epidermal growth factor receptor transactivation impairs redox balance in vascular smooth muscle cells and facilitates vascular contraction
por: Prado, Alejandro F., et al.
Publicado: (2018)

Actions of Calcium Channel Blockers on Vascular Proteoglycan Synthesis: Relationship to Atherosclerosis
por: Survase, Soniya, et al.
Publicado: (2005)

New Approaches to Regulating the Chondroitin/Dermatan Sulfate Glycosaminoglycan Component of the Vascular Extracellular Matrix
por: Nigro, Julie, et al.
Publicado: (2005)

Protease-Activated Receptor 2 Promotes Pro-Atherogenic Effects through Transactivation of the VEGF Receptor 2 in Human Vascular Smooth Muscle Cells
por: Indrakusuma, Ira, et al.
Publicado: (2017)

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
por: Yang, Weiwei, et al.
Publicado: (2011)

Alpha1a-Adrenoceptor Genetic Variant Triggers Vascular Smooth Muscle Cell Hyperproliferation and Agonist Induced Hypertrophy via EGFR Transactivation Pathway
por: Gradinaru, Irina, et al.
Publicado: (2015)

Transcriptome Profiling in Systems Vascular Medicine
por: Xu, Suowen
Publicado: (2017)

Contribution of oxidative stress and growth factor receptor transactivation in natriuretic peptide receptor C-mediated attenuation of hyperproliferation of vascular smooth muscle cells from SHR
por: Rahali, Sofiane, et al.
Publicado: (2018)

Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation
por: Jambrina, Pablo G., et al.
Publicado: (2015)

B-cell clonogenic activity of HIV-1 p17 variants is driven by PAR1-mediated EGF transactivation
por: Giagulli, Cinzia, et al.
Publicado: (2020)

Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype
por: Zheng, Feimeng, et al.
Publicado: (2016)

Targeting PAR2 Overcomes Gefitinib Resistance in Non-Small-Cell Lung Cancer Cells Through Inhibition of EGFR Transactivation
por: Jiang, Yuhong, et al.
Publicado: (2021)

STAT3 enhances the constitutive activity of AGC kinases in melanoma by transactivating PDK1
por: Picco, María Elisa, et al.
Publicado: (2019)

Resveratrol's Impact on Vascular Smooth Muscle Cells Hyporeactivity: The Role of Rho-Kinase Inhibition
por: Wiciński, Michał, et al.
Publicado: (2020)

Transactivation of proto-oncogene c-Myc by hepatitis B virus transactivator MHBs(t167)
por: LUN, YONG-ZHI, et al.
Publicado: (2014)

A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway Smooth Muscle Relaxation by TAS2R14
por: Woo, Jung-A A., et al.
Publicado: (2023)

Editorial: Biomechanics in Translation: From Vascular Biology to Cardiovascular Drug Discovery
por: Li, Zhiyong, et al.
Publicado: (2020)

Engineering Smooth Muscle to Understand Extracellular Matrix Remodeling and Vascular Disease
por: Yarbrough, Danielle, et al.
Publicado: (2022)

C1q/TNF‐related protein 4 mediates proliferation and migration of vascular smooth muscle cells during vascular remodelling
por: Liu, Jingying, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_56t6kvgan4gtf68cma646rjgdb