Small Molecule BRD4 Inhibitors Apabetalone and JQ1 Rescues Endothelial Cells Dysfunction, Protects Monolayer Integrity and Reduces Midkine Expression

NF-κB signaling is a key regulator of inflammation and atherosclerosis. NF-κB cooperates with bromodomain-containing protein 4 (BRD4), a transcriptional and epigenetic regulator, in endothelial inflammation. This study aimed to investigate whether BRD4 inhibition would prevent the proinflammatory re...

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Detalles Bibliográficos
Autores principales: Shahid, Sidra, Pantakani, Marlena, Binder, Lutz, Fischer, Andreas, Pantakani, Krishna, Asif, Abdul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692972/
https://www.ncbi.nlm.nih.gov/pubmed/36364277
http://dx.doi.org/10.3390/molecules27217453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692972/
https://www.ncbi.nlm.nih.gov/pubmed/36364277
http://dx.doi.org/10.3390/molecules27217453

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