Newly Synthesized Melphalan Analogs Induce DNA Damage and Mitotic Catastrophe in Hematological Malignant Cancer Cells

Myeloablative therapy with highdoses of the cytostatic drug melphalan (MEL) in preparation for hematopoietic cell transplantation is the standard of care for multiple myeloma (MM) patients. Melphalan is a bifunctional alkylating agent that covalently binds to nucleophilic sites in the DNA and effect...

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Detalles Bibliográficos
Autores principales: Poczta, Anastazja, Krzeczyński, Piotr, Ionov, Maksim, Rogalska, Aneta, Gaipl, Udo S., Marczak, Agnieszka, Lubgan, Dorota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693175/
https://www.ncbi.nlm.nih.gov/pubmed/36430734
http://dx.doi.org/10.3390/ijms232214258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693175/
https://www.ncbi.nlm.nih.gov/pubmed/36430734
http://dx.doi.org/10.3390/ijms232214258

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