The Trypanosoma cruzi TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2′-Deoxyuridine and Tubercidin Analogues

Among the scarce validated drug targets against Chagas disease (CD), caused by Trypanosoma cruzi, the parasite’s nucleoside salvage system has recently attracted considerable attention. Although the trypanocidal activity of tubercidin (7-deazapurine) has long been known, the identification of a clas...

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Detalles Bibliográficos
Autores principales: Aldfer, Mustafa M., Alfayez, Ibrahim A., Elati, Hamza A. A., Gayen, Nilanjana, Elmahallawy, Ehab Kotb, Milena Murillo, Ana, Marsiccobetre, Sabrina, Van Calenbergh, Serge, Silber, Ariel M., de Koning, Harry P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693223/
https://www.ncbi.nlm.nih.gov/pubmed/36432150
http://dx.doi.org/10.3390/molecules27228045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693223/
https://www.ncbi.nlm.nih.gov/pubmed/36432150
http://dx.doi.org/10.3390/molecules27228045

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