Cargando…

Old and New Facts and Speculations on the Role of the B Cell Receptor in the Origin of Chronic Lymphocytic Leukemia

The engagement of the B cell receptor (BcR) on the surface of leukemic cells represents a key event in chronic lymphocytic leukemia (CLL) since it can lead to the maintenance and expansion of the neoplastic clone. This notion was initially suggested by observations of the CLL BcR repertoire and of c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bagnara, Davide, Mazzarello, Andrea Nicola, Ghiotto, Fabio, Colombo, Monica, Cutrona, Giovanna, Fais, Franco, Ferrarini, Manlio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693457/ https://www.ncbi.nlm.nih.gov/pubmed/36430731 http://dx.doi.org/10.3390/ijms232214249

Ejemplares similares

Berberine affects mitochondrial activity and cell growth of leukemic cells from chronic lymphocytic leukemia patients
por: Ravera, Silvia, et al.
Publicado: (2020)

Characterizing Features of Human Circulating B Cells Carrying CLL-Like Stereotyped Immunoglobulin Rearrangements
por: Bagnara, Davide, et al.
Publicado: (2022)

Tracing CLL-biased stereotyped immunoglobulin gene rearrangements in normal B cell subsets using a high-throughput immunogenetic approach
por: Colombo, Monica, et al.
Publicado: (2020)

A High Percentage of CD16+ Monocytes Correlates with the Extent of Bone Erosion in Chronic Lymphocytic Leukemia Patients: The Impact of Leukemic B Cells in Monocyte Differentiation and Osteoclast Maturation
por: Giannoni, Paolo, et al.
Publicado: (2022)

Multiple Distinct Sets of Stereotyped Antigen Receptors Indicate a Role for Antigen in Promoting Chronic Lymphocytic Leukemia
por: Messmer, Bradley T., et al.
Publicado: (2004)

Post-Transformation IGHV-IGHD-IGHJ Mutations in Chronic Lymphocytic Leukemia B Cells: Implications for Mutational Mechanisms and Impact on Clinical Course
por: Bagnara, Davide, et al.
Publicado: (2021)

Unraveling the Bone Tissue Microenvironment in Chronic Lymphocytic Leukemia
por: Giannoni, Paolo, et al.
Publicado: (2023)

Metformin inhibits cell cycle progression of B-cell chronic lymphocytic leukemia cells
por: Bruno, Silvia, et al.
Publicado: (2015)

Itch in Liver Disease: Facts and Speculations
por: Ghent, Cameron N., et al.
Publicado: (1979)

The spectrum of subclonal TP53 mutations in chronic lymphocytic leukemia: A next generation sequencing retrospective study
por: De Luca, Giuseppa, et al.
Publicado: (2022)

Transgene flow: Facts, speculations and possible countermeasures
por: Ryffel, Gerhart U
Publicado: (2014)

The Sixth Mass Extinction: fact, fiction or speculation?
por: Cowie, Robert H., et al.
Publicado: (2022)

Lymphocyte Doubling Time As A Key Prognostic Factor To Predict Time To First Treatment In Early-Stage Chronic Lymphocytic Leukemia
por: Morabito, Fortunato, et al.
Publicado: (2021)

Unexpected CD5(+) B Cell Lymphocytosis during SARS-CoV-2 Infection: Relevance for the Pathophysiology of Chronic Lymphocytic Leukemia
por: Mazzarello, Andrea Nicola, et al.
Publicado: (2023)

One, two, three... infinity: facts and speculations of science
por: Gamow, George
Publicado: (1988)

SARS-CoV-2 Infection in Dogs and Cats: Facts and Speculations
por: Decaro, Nicola, et al.
Publicado: (2021)

Small nucleolar RNAs as new biomarkers in chronic lymphocytic leukemia
por: Ronchetti, Domenica, et al.
Publicado: (2013)

Editorial: Role of the antigen receptor in the pathogenesis of B-cell lymphoid malignancies
por: Agathangelidis, Andreas, et al.
Publicado: (2023)

Interleukin 21 Controls mRNA and MicroRNA Expression in CD40-Activated Chronic Lymphocytic Leukemia Cells
por: De Cecco, Loris, et al.
Publicado: (2015)

Chronic lymphocytic leukemia cells impair osteoblastogenesis and promote osteoclastogenesis: role of TNFα, IL-6 and IL-11 cytokines
por: Giannoni, Paolo, et al.
Publicado: (2020)

Genes selection using deep learning and explainable artificial intelligence for chronic lymphocytic leukemia predicting the need and time to therapy
por: Morabito, Fortunato, et al.
Publicado: (2023)

Speculations on the Evolutionary Origins of System Justification
por: Jost, John T., et al.
Publicado: (2018)

Relevance of Stereotyped B-Cell Receptors in the Context of the Molecular, Cytogenetic and Clinical Features of Chronic Lymphocytic Leukemia
por: Maura, Francesco, et al.
Publicado: (2011)

NEAT1 Long Isoform Is Highly Expressed in Chronic Lymphocytic Leukemia Irrespectively of Cytogenetic Groups or Clinical Outcome
por: Ronchetti, Domenica, et al.
Publicado: (2020)

LINC00152 expression in normal and Chronic Lymphocytic Leukemia B cells
por: Matis, Serena, et al.
Publicado: (2021)

Time to first treatment and P53 dysfunction in chronic lymphocytic leukaemia: results of the O-CLL1 study in early stage patients
por: Monti, Paola, et al.
Publicado: (2020)

Various Jobs of Proteolytic Enzymes in Skeletal Muscle during Unloading: Facts and Speculations
por: Kachaeva, E. V., et al.
Publicado: (2012)

What Motivates Speculators to Speculate?
por: Gemeda, Bedane S., et al.
Publicado: (2019)

Heterogeneity of TP53 Mutations and P53 Protein Residual Function in Cancer: Does It Matter?
por: Monti, Paola, et al.
Publicado: (2020)

MiR-146b-5p regulates IL-23 receptor complex expression in chronic lymphocytic leukemia cells
por: Matis, Serena, et al.
Publicado: (2022)

Interstitial Cells of Cajal (ICC) and Gastrointestinal Stromal Tumor (GIST): facts, speculations, and myths
por: Min, K W, et al.
Publicado: (2006)

Antitumor Effects of PRIMA-1 and PRIMA-1(Met) (APR246) in Hematological Malignancies: Still a Mutant P53-Dependent Affair?
por: Menichini, Paola, et al.
Publicado: (2021)

The mechanism of benzene-induced leukemia: a hypothesis and speculations on the causes of leukemia.
por: Smith, M T
Publicado: (1996)

Autoimmune Cytopenias in Chronic Lymphocytic Leukemia, Facts and Myths
por: Tandra, Pavankumar, et al.
Publicado: (2013)

Hepatocyte Growth Factor: A Microenvironmental Resource for Leukemic Cell Growth
por: Giannoni, Paolo, et al.
Publicado: (2019)

Linguistic speculations
por: Householder, Fred W. (Fred Walter), 1913-
Publicado: (1971)

Medical Speculations
Publicado: (1804)

Electrophoresis in nanochannels: brief review and speculation
por: Baldessari, Fabio, et al.
Publicado: (2006)

Novel Method for High-Throughput Full-Length IGHV-D-J Sequencing of the Immune Repertoire from Bulk B-Cells with Single-Cell Resolution
por: Vergani, Stefano, et al.
Publicado: (2017)

Characterization of the Intraclonal Complexity of Chronic Lymphocytic Leukemia B Cells: Potential Influences of B-Cell Receptor Crosstalk with Other Stimuli
por: Mazzarello, Andrea N., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2bloo60925ip070h949i7frhp8