High-Throughput Metabolic Soft-Spot Identification in Liver Microsomes by LC/UV/MS: Application of a Single Variable Incubation Time Approach

CYP-mediated fast metabolism may lead to poor bioavailability, fast drug clearance and significant drug interaction. Thus, metabolic stability screening in human liver microsomes (HLM) followed by metabolic soft-spot identification (MSSID) is routinely conducted in drug discovery. Liver microsomal i...

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Detalles Bibliográficos
Autores principales: Zhu, Yanlin, Chen, Guiying, Zhang, Kerong, Chen, Chang, Chen, Weiqing, Zhu, Mingshe, Jiang, Hongliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693510/
https://www.ncbi.nlm.nih.gov/pubmed/36432161
http://dx.doi.org/10.3390/molecules27228058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693510/
https://www.ncbi.nlm.nih.gov/pubmed/36432161
http://dx.doi.org/10.3390/molecules27228058

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