Long-Term Consumption of Food-Derived Chlorogenic Acid Protects Mice against Acetaminophen-Induced Hepatotoxicity via Promoting PINK1-Dependent Mitophagy and Inhibiting Apoptosis

Hepatotoxicity brought on by acetaminophen (APAP) is significantly impacted by mitochondrial dysfunction. Mitophagy, particularly PINK1-mediated mitophagy, maintains the stability of cell function by eliminating damaged mitochondria. One of the most prevalent dietary polyphenols, chlorogenic acid (C...

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Detalles Bibliográficos
Autores principales: Hu, Bangyan, Li, Jin, Gong, Daoyin, Dai, Yuan, Wang, Ping, Wan, Lihong, Xu, Shijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693533/
https://www.ncbi.nlm.nih.gov/pubmed/36355956
http://dx.doi.org/10.3390/toxics10110665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693533/
https://www.ncbi.nlm.nih.gov/pubmed/36355956
http://dx.doi.org/10.3390/toxics10110665

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