Aging Impairs Adaptive Unfolded Protein Response and Drives Beta Cell Dedifferentiation in Humans

CONTEXT: Diabetes is an age-related disease; however, the mechanism underlying senescent beta cell failure is still unknown. OBJECTIVE: The present study was designed to investigate whether and how the differentiated state was altered in senescent human beta cells by excluding the effects of impaire...

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Detalles Bibliográficos
Autores principales: Song, Jiaxi, Ni, Qicheng, Sun, Jiajun, Xie, Jing, Liu, Jianmin, Ning, Guang, Wang, Weiqing, Wang, Qidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Clinical Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693768/
https://www.ncbi.nlm.nih.gov/pubmed/36125175
http://dx.doi.org/10.1210/clinem/dgac535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693768/
https://www.ncbi.nlm.nih.gov/pubmed/36125175
http://dx.doi.org/10.1210/clinem/dgac535

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