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Aging Impairs Adaptive Unfolded Protein Response and Drives Beta Cell Dedifferentiation in Humans
CONTEXT: Diabetes is an age-related disease; however, the mechanism underlying senescent beta cell failure is still unknown. OBJECTIVE: The present study was designed to investigate whether and how the differentiated state was altered in senescent human beta cells by excluding the effects of impaire...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693768/ https://www.ncbi.nlm.nih.gov/pubmed/36125175 http://dx.doi.org/10.1210/clinem/dgac535 |