Cargando…

Non-Viral Gene Therapy in Trabecular Meshwork Cells to Prevent Fibrosis in Minimally Invasive Glaucoma Surgery

The primary cause of failure for minimally invasive glaucoma surgery (MIGS) is fibrosis in the trabecular meshwork (TM) that regulates the outflow of aqueous humour, and no anti-fibrotic drug is available for intraocular use in MIGS. The myocardin-related transcription factor/serum response factor (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Jinyuan, Tan, Greymi, Thong, Kai Xin, Kafetzis, Konstantinos N., Vallabh, Neeru, Sheridan, Carl M., Sato, Yusuke, Harashima, Hideyoshi, Tagalakis, Aristides D., Yu-Wai-Man, Cynthia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693853/ https://www.ncbi.nlm.nih.gov/pubmed/36432663 http://dx.doi.org/10.3390/pharmaceutics14112472

Ejemplares similares

Novel PEGylated Lipid Nanoparticles Have a High Encapsulation Efficiency and Effectively Deliver MRTF-B siRNA in Conjunctival Fibroblasts
por: Sanghani, Amisha, et al.
Publicado: (2021)

Minimally Invasive Glaucoma Surgery—to Remove or Preserve the Trabecular Meshwork: That is the Question?
por: Dada, Tanuj, et al.
Publicado: (2021)

An Optimized Method to Decellularize Human Trabecular Meshwork
por: Crouch, Devon J., et al.
Publicado: (2022)

Histological Findings in the Trabecular Meshwork of a Patient with Atopic Glaucoma
por: Kase, Satoru, et al.
Publicado: (2017)

Investigating the Relationship between Glaucoma Prevalence and Trabecular Meshwork Length
por: Choi, Wungrak, et al.
Publicado: (2021)

Cell-Based Therapies for Trabecular Meshwork Regeneration to Treat Glaucoma
por: Mallick, Shayshadri, et al.
Publicado: (2021)

Decorin treatment for reversing trabecular meshwork fibrosis in open-angle glaucoma
por: Hill, Lisa J, et al.
Publicado: (2016)

Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma
por: Sun, Hong, et al.
Publicado: (2019)

Autoantigens in the trabecular meshwork and glaucoma‐specific alterations in the natural autoantibody repertoire
por: Beutgen, Vanessa M, et al.
Publicado: (2020)

Switch to Autophagy the Key Mechanism for Trabecular Meshwork Death in Severe Glaucoma
por: Rao, Aparna, et al.
Publicado: (2021)

Technological advances in ocular trabecular meshwork in vitro models for glaucoma research
por: Bikuna‐Izagirre, Maria, et al.
Publicado: (2022)

Progenitors for the Corneal Endothelium and Trabecular Meshwork: A Potential Source for Personalized Stem Cell Therapy in Corneal Endothelial Diseases and Glaucoma
por: Yu, Wing Yan, et al.
Publicado: (2011)

Genome-Wide RNA Sequencing of Human Trabecular Meshwork Cells Treated with TGF-β1: Relevance to Pseudoexfoliation Glaucoma
por: Roodnat, Anton W., et al.
Publicado: (2022)

Human Trabecular Meshwork Progenitors
por: Zhu, Qin, et al.
Publicado: (2019)

Mitochondrial Damage in the Trabecular Meshwork Occurs Only in Primary Open-Angle Glaucoma and in Pseudoexfoliative Glaucoma
por: Izzotti, Alberto, et al.
Publicado: (2011)

Replacement of the Trabecular Meshwork Cells—A Way Ahead in IOP Control?
por: Fan, Xiaochen, et al.
Publicado: (2021)

Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma
por: Zhong, Yisheng, et al.
Publicado: (2013)

Physiological function of myocilin and its role in the pathogenesis of glaucoma in the trabecular meshwork (Review)
por: Wang, Hongwei, et al.
Publicado: (2019)

Protective Effects of Rapamycin on Trabecular Meshwork Cells in Glucocorticoid-Induced Glaucoma Mice
por: Zhu, Xiaolu, et al.
Publicado: (2020)

Evaluation of the Relationship Between Age and Trabecular Meshwork Height to Predict the Risk of Glaucoma
por: Choi, Wungrak, et al.
Publicado: (2020)

A 3D Model of Human Trabecular Meshwork for the Research Study of Glaucoma
por: Tirendi, Sara, et al.
Publicado: (2020)

Influence of Anti-Glaucoma Drugs on Uptake of Extracellular Vesicles by Trabecular Meshwork Cells
por: Tabak, Saray, et al.
Publicado: (2021)

Trabecular Meshwork Mitochondrial Function and Oxidative Stress: Clues to Racial Disparities of Glaucoma
por: Wu, Hongli, et al.
Publicado: (2021)

Exploiting biomaterial approaches to manufacture an artificial trabecular meshwork: A progress report
por: Crouch, Devon J., et al.
Publicado: (2021)

YAP and TAZ mediate steroid-induced alterations in the trabecular meshwork cytoskeleton in human trabecular meshwork cells
por: Peng, Jie, et al.
Publicado: (2018)

Receptor-Associated Prorenin System in the Trabecular Meshwork of Patients with Primary Open-Angle Glaucoma and Neovascular Glaucoma
por: Ishizuka, Erdal Tan, et al.
Publicado: (2020)

Scanning electron microscopy of the trabecular meshwork: Understanding the pathogenesis of primary angle closure glaucoma
por: Sihota, Ramanjit, et al.
Publicado: (2012)

Enhanced cytomegalovirus infection in human trabecular meshwork cells and its implication in glaucoma pathogenesis
por: Choi, Jin A, et al.
Publicado: (2017)

GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans
por: Nair, K. Saidas, et al.
Publicado: (2021)

Apoptosis in the trabecular meshwork of glaucomatous patients
por: Baleriola, Jimena, et al.
Publicado: (2008)

Two-photon imaging of the trabecular meshwork
por: Ammar, David A., et al.
Publicado: (2010)

Surgery on the Trabecular Meshwork: Histopathological Evidence
por: Bhartiya, Shibal, et al.
Publicado: (2015)

Oxidative stress and antioxidants in the trabecular meshwork
por: Wang, Mingxuan, et al.
Publicado: (2019)

Comparative Study of the Effects of Trabecular Meshwork Outflow Drugs on the Permeability and Nitric Oxide Production in Trabecular Meshwork Cells
por: Kim, Jae Woo
Publicado: (2017)

Changes in the deep vasculature assessed using anterior segment OCT angiography following trabecular meshwork targeted minimally invasive glaucoma surgery
por: Okamoto, Yoko, et al.
Publicado: (2022)

Pro-fibrotic pathway activation in trabecular meshwork and lamina cribrosa is the main driving force of glaucoma
por: Zhavoronkov, Alex, et al.
Publicado: (2016)

HDAC Inhibitor-Mediated Epigenetic Regulation of Glaucoma-Associated TGFβ2 in the Trabecular Meshwork
por: Bermudez, Jaclyn Y., et al.
Publicado: (2016)

Effects of Trabecular Meshwork Width and Schlemm’s Canal Area on Intraocular Pressure Reduction in Glaucoma Patients
por: Chung, Hyun Woo, et al.
Publicado: (2021)

Global and Comparative Proteome Signatures in the Lens Capsule, Trabecular Meshwork, and Iris of Patients With Pseudoexfoliation Glaucoma
por: Sahay, Prity, et al.
Publicado: (2022)

Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma
por: Patel, Pinkal D., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0ts8l7nk20s5do5ijjli74imst