A lysine residue from an extracellular turret switches the ion preference in a Cav3 T-Type channel from calcium to sodium ions

Cav3 T-type calcium channels from great pond snail Lymnaea stagnalis have a selectivity-filter ring of five acidic residues, EE(D)DD. Splice variants with exons 12b or 12a spanning the extracellular loop between the outer helix IIS5 and membrane-descending pore helix IIP1 (IIS5-P1) in Domain II of t...

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Detalles Bibliográficos
Autores principales: Guan, Wendy, Orellana, Kaidy G., Stephens, Robert F., Zhorov, Boris S., Spafford, J. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694082/
https://www.ncbi.nlm.nih.gov/pubmed/36272643
http://dx.doi.org/10.1016/j.jbc.2022.102621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694082/
https://www.ncbi.nlm.nih.gov/pubmed/36272643
http://dx.doi.org/10.1016/j.jbc.2022.102621

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