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SVCT2–mediated ascorbic acid uptake buffers stress responses via DNA hydroxymethylation reprogramming of S100 calcium-binding protein A4 gene

Vitamin C, a key antioxidant in the central nervous system, cycles between ascorbic acid and dehydroascorbic acid under pathophysiological conditions. Clinical evidence supports that the absence of vitamin C may be linked to depressive symptoms, but much less is known about the mechanism. Herein, we...

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Detalles Bibliográficos
Autores principales: Han, Qian-Qian, Wu, Peng-Fei, Li, Yi-Heng, Cao, Yu, Chen, Jian-Guo, Wang, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694147/
https://www.ncbi.nlm.nih.gov/pubmed/36436457
http://dx.doi.org/10.1016/j.redox.2022.102543