Effects of Heme Site (FA1) Ligands Bilirubin, Biliverdin, Hemin, and Methyl Orange on the Albumin Binding of Site I Marker Warfarin: Complex Allosteric Interactions

Human serum albumin (HSA) is the most abundant plasma protein in circulation. The three most important drug-binding sites on HSA are Sudlow’s Site I (subdomain IIA), Sudlow’s Site II (subdomain IIIA), and Heme site (subdomain IB). Heme site and Site I are allosterically coupled; therefore, their lig...

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Detalles Bibliográficos
Autores principales: Lemli, Beáta, Lomozová, Zuzana, Huber, Tamás, Lukács, András, Poór, Miklós
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694159/
https://www.ncbi.nlm.nih.gov/pubmed/36430492
http://dx.doi.org/10.3390/ijms232214007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694159/
https://www.ncbi.nlm.nih.gov/pubmed/36430492
http://dx.doi.org/10.3390/ijms232214007

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