Reactivity of Covalent Fragments and Their Role in Fragment Based Drug Discovery

Fragment based drug discovery has long been used for the identification of new ligands and interest in targeted covalent inhibitors has continued to grow in recent years, with high profile drugs such as osimertinib and sotorasib gaining FDA approval. It is therefore unsurprising that covalent fragme...

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Detalles Bibliográficos
Autores principales: McAulay, Kirsten, Bilsland, Alan, Bon, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694498/
https://www.ncbi.nlm.nih.gov/pubmed/36355538
http://dx.doi.org/10.3390/ph15111366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694498/
https://www.ncbi.nlm.nih.gov/pubmed/36355538
http://dx.doi.org/10.3390/ph15111366

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