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Reactivity of Covalent Fragments and Their Role in Fragment Based Drug Discovery
Fragment based drug discovery has long been used for the identification of new ligands and interest in targeted covalent inhibitors has continued to grow in recent years, with high profile drugs such as osimertinib and sotorasib gaining FDA approval. It is therefore unsurprising that covalent fragme...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694498/ https://www.ncbi.nlm.nih.gov/pubmed/36355538 http://dx.doi.org/10.3390/ph15111366 |