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An Immunconjugate Vaccine Alters Distribution and Reduces the Antinociceptive, Behavioral and Physiological Effects of Fentanyl in Male and Female Rats

Fentanyl (FEN) is a potent synthetic opioid associated with increasing incidence of opioid use disorder (OUD) and fatal opioid overdose. Vaccine immunotherapy for FEN-associated disorders may be a viable therapeutic strategy. Here, we expand and confirm our previous study in mice showing immunologic...

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Detalles Bibliográficos
Autores principales: Haile, Colin N., Baker, Miah D., Sanchez, Sergio A., Lopez Arteaga, Carlos A., Duddupudi, Anantha L., Cuny, Gregory D., Norton, Elizabeth B., Kosten, Thomas R., Kosten, Therese A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694531/
https://www.ncbi.nlm.nih.gov/pubmed/36365109
http://dx.doi.org/10.3390/pharmaceutics14112290