Identification of Active Compounds against Melanoma Growth by Virtual Screening for Non-Classical Human DHFR Inhibitors

Antifolates such as methotrexate (MTX) have been largely known as anticancer agents because of their role in blocking nucleic acid synthesis and cell proliferation. Their mechanism of action lies in their ability to inhibit enzymes involved in the folic acid cycle, especially human dihydrofolate red...

Descripción completa

Detalles Bibliográficos
Autores principales: Vásquez, Andrés Felipe, Gómez, Luis Alberto, González Barrios, Andrés, Riaño-Pachón, Diego M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694616/
https://www.ncbi.nlm.nih.gov/pubmed/36430425
http://dx.doi.org/10.3390/ijms232213946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694616/
https://www.ncbi.nlm.nih.gov/pubmed/36430425
http://dx.doi.org/10.3390/ijms232213946

Ejemplares similares