Dual Topoisomerase I/II Inhibition-Induced Apoptosis and Necro-Apoptosis in Cancer Cells by a Novel Ciprofloxacin Derivative via RIPK1/RIPK3/MLKL Activation

Fluoroquinolones (FQs) are synthetic broad-spectrum antimicrobial agents that have been recently repurposed to anticancer candidates. Designing new derivatives of FQs with different moieties to target DNA topoisomerases could improve their anticancer efficacy. The present study aimed to synthesize a...

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Detalles Bibliográficos
Autores principales: Alaaeldin, Rania, Abdel-Rahman, Islam M., Ali, Fares E. M., Bekhit, Amany Abdlrehim, Elhamadany, Eyad Y., Zhao, Qing-Li, Cui, Zheng-Guo, Fathy, Moustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694631/
https://www.ncbi.nlm.nih.gov/pubmed/36432094
http://dx.doi.org/10.3390/molecules27227993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694631/
https://www.ncbi.nlm.nih.gov/pubmed/36432094
http://dx.doi.org/10.3390/molecules27227993

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