Myostatin Knockout Affects Mitochondrial Function by Inhibiting the AMPK/SIRT1/PGC1α Pathway in Skeletal Muscle

SIMPLE SUMMARY: Myostatin (Mstn) is a negative regulator of skeletal muscle mass, and its deletion leads to reduced mitochondrial function. However, the exact regulatory mechanism remains unclear. In this study, we used CRISPR/Cas9 to generate myostatin-knockout (Mstn-KO) mice via pronuclear microin...

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Detalles Bibliográficos
Autores principales: Gu, Mingjuan, Wei, Zhuying, Wang, Xueqiao, Gao, Yang, Wang, Dong, Liu, Xuefei, Bai, Chunling, Su, Guanghua, Yang, Lei, Li, Guangpeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694677/
https://www.ncbi.nlm.nih.gov/pubmed/36430183
http://dx.doi.org/10.3390/ijms232213703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694677/
https://www.ncbi.nlm.nih.gov/pubmed/36430183
http://dx.doi.org/10.3390/ijms232213703

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