CYP2C9 Polymorphism Influence in PK/PD Model of Naproxen and 6-O-Desmethylnaproxen in Oral Fluid

Polymorphisms in CYP2C9 can significantly interfere with the pharmacokinetic (PK) and pharmacodynamic (PD) parameters of nonsteroidal anti-inflammatory drugs (NSAIDs), including naproxen. The present research aimed to study the PK/PD parameters of naproxen and its metabolite, 6-O-desmethylnaproxen,...

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Detalles Bibliográficos
Autores principales: Oliveira, Gabriela Moraes, Dionísio, Thiago José, Siqueira-Sandrin, Viviane Silva, Ferrari, Leticia Alves de Lima, Bolani, Bruna, Parisi, Viviane Aparecida, Polanco, Nelson Leonel Del Hierro, Colombini-Ishikiriama, Bella Luna, Faria, Flávio Augusto Cardoso, Santos, Carlos Ferreira, Calvo, Adriana Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694679/
https://www.ncbi.nlm.nih.gov/pubmed/36422246
http://dx.doi.org/10.3390/metabo12111106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694679/
https://www.ncbi.nlm.nih.gov/pubmed/36422246
http://dx.doi.org/10.3390/metabo12111106

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