Genistein Modified with 8-Prenyl Group Suppresses Osteoclast Activity Directly via Its Prototype but Not Metabolite by Gut Microbiota

Postmenopausal osteoporosis is a significant threat to human health globally. Genistein, a soy-derived isoflavone, is regarded as a promising anti-osteoporosis drug with the effects of promoting osteoblastogenesis and suppressing osteoclastogenesis. However, its oral bioavailability (6.8%) is limite...

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Detalles Bibliográficos
Autores principales: Qiu, Zuo-Cheng, Zhang, Feng-Xiang, Hu, Xue-Ling, Zhang, Yang-Yang, Tang, Zi-Ling, Zhang, Jie, Yang, Li, Wong, Man-Sau, Chen, Jia-Xu, Xiao, Hui-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694937/
https://www.ncbi.nlm.nih.gov/pubmed/36431913
http://dx.doi.org/10.3390/molecules27227811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694937/
https://www.ncbi.nlm.nih.gov/pubmed/36431913
http://dx.doi.org/10.3390/molecules27227811

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