Inhibition of Calpain Attenuates Degeneration of Substantia Nigra Neurons in the Rotenone Rat Model of Parkinson’s Disease

In the central nervous system (CNS), calcium homeostasis is a critical determinant of neuronal survival. Calpain, a calcium-dependent neutral protease, is widely expressed in the brain, including substantia nigra (SN) dopaminergic (DA) neurons. Though calpain is implicated in human Parkinson’s disea...

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Detalles Bibliográficos
Autores principales: Zaman, Vandana, Drasites, Kelsey P., Myatich, Ali, Shams, Ramsha, Shields, Donald C., Matzelle, Denise, Haque, Azizul, Banik, Narendra L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694996/
https://www.ncbi.nlm.nih.gov/pubmed/36430329
http://dx.doi.org/10.3390/ijms232213849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694996/
https://www.ncbi.nlm.nih.gov/pubmed/36430329
http://dx.doi.org/10.3390/ijms232213849

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