Cargando…

Protrusion of KCNJ13 Gene Knockout Retinal Pigment Epithelium Due to Oxidative Stress–Induced Cell Death

PURPOSE: This study was performed to elucidate the mechanisms of morphological abnormalities in a Leber congenital amaurosis 16 (LCA16) cell model using KCNJ13 knockout (KO) retinal pigment epithelial cells derived from human iPS cells (hiPSC-RPE). METHODS: In KCNJ13 KO and wild-type hiPSC-RPE cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kanzaki, Yuki, Fujita, Hirofumi, Sato, Keita, Hosokawa, Mio, Matsumae, Hiroshi, Morizane, Yuki, Ohuchi, Hideyo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2022
Materias:	Retinal Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695160/ https://www.ncbi.nlm.nih.gov/pubmed/36413373 http://dx.doi.org/10.1167/iovs.63.12.29

Ejemplares similares

KCNJ13 Gene Deletion Impairs Cell Alignment and Phagocytosis in Retinal Pigment Epithelium Derived from Human-Induced Pluripotent Stem Cells
por: Kanzaki, Yuki, et al.
Publicado: (2020)

Modulation of Tmem135 Leads to Retinal Pigmented Epithelium Pathologies in Mice
por: Landowski, Michael, et al.
Publicado: (2020)

Partially Differentiated Neuroretinal Cells Promote Maturation of the Retinal Pigment Epithelium
por: Singh, Deepti, et al.
Publicado: (2020)

The Role of IRE-XBP1 Pathway in Regulation of Retinal Pigment Epithelium Tight Junctions
por: Ma, Jacey H., et al.
Publicado: (2016)

Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction
por: Escrevente, Cristina, et al.
Publicado: (2021)

Characterization and Regulation of Carrier Proteins of Mitochondrial Glutathione Uptake in Human Retinal Pigment Epithelium Cells
por: Wang, Mo, et al.
Publicado: (2019)

Autofluorescent Granules of the Human Retinal Pigment Epithelium: Phenotypes, Intracellular Distribution, and Age-Related Topography
por: Bermond, Katharina, et al.
Publicado: (2020)

Prolonged Lifetimes of Histologic Autofluorescence in Ectopic Retinal Pigment Epithelium in Age-Related Macular Degeneration
por: Simon, Rowena, et al.
Publicado: (2022)

Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration
por: Storm, Tina, et al.
Publicado: (2019)

Dopamine 2 Receptor Signaling Controls the Daily Burst in Phagocytic Activity in the Mouse Retinal Pigment Epithelium
por: Goyal, Varunika, et al.
Publicado: (2020)

Knockdown of Claudin-19 in the Retinal Pigment Epithelium Is Accompanied by Slowed Phagocytosis and Increased Expression of SQSTM1
por: Liu, Fanfei, et al.
Publicado: (2021)

Hypoxia Induces Galectin-1 Expression Via Autoinduction of Placental Growth Factor in Retinal Pigment Epithelium Cells
por: Yamamoto, Taku, et al.
Publicado: (2021)

Autofluorescent Organelles Within the Retinal Pigment Epithelium in Human Donor Eyes With and Without Age-Related Macular Degeneration
por: Bermond, Katharina, et al.
Publicado: (2022)

Anatomical and Gene Expression Changes in the Retinal Pigmented Epithelium Atrophy 1 (rpea1) Mouse: A Potential Model of Serous Retinal Detachment
por: Luna, Gabriel, et al.
Publicado: (2016)

Sensitivity of the Dorsal-Central Retinal Pigment Epithelium to Sodium Iodate-Induced Damage Is Associated With Overlying M-Cone Photoreceptors in Mice
por: Lian, Lili, et al.
Publicado: (2022)

Retinal pigment epithelium hyperplasia overlying pigment epithelial detachment in age-related macular degeneration can masquerade as neovascularization on optical coherence tomography angiography
por: Chen, Ling, et al.
Publicado: (2018)

Retinal Development and Pathophysiology in Kcnj13 Knockout Mice
por: Jiao, Xiaodong, et al.
Publicado: (2022)

Impaired Lysosome Reformation in Chloroquine-Treated Retinal Pigment Epithelial Cells
por: Cardoso, M. Helena, et al.
Publicado: (2023)

Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal Progenitor Cells
por: Frasson, Lorena Teixeira, et al.
Publicado: (2021)

Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease
por: Hayes, Matthew J., et al.
Publicado: (2019)

Resveratrol Protects Against Hydroquinone-Induced Oxidative Threat in Retinal Pigment Epithelial Cells
por: Neal, Samantha E., et al.
Publicado: (2020)

Genomic Disruption of VEGF-A Expression in Human Retinal Pigment Epithelial Cells Using CRISPR-Cas9 Endonuclease
por: Yiu, Glenn, et al.
Publicado: (2016)

Morphometric Analysis of Retinal Pigment Epithelial Cells From C57BL/6J Mice During Aging
por: Kim, Yong-Kyu, et al.
Publicado: (2021)

N-Acetylcysteine Amide Protects Against Oxidative Stress–Induced Microparticle Release From Human Retinal Pigment Epithelial Cells
por: Carver, Kyle A., et al.
Publicado: (2016)

Oxidized Lipoprotein Uptake Through the CD36 Receptor Activates the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells
por: Gnanaguru, Gopalan, et al.
Publicado: (2016)

Effectively Intervening Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells With a Combination of ROCK and TGF-β Signaling Inhibitors
por: Chen, Yi, et al.
Publicado: (2021)

Diabetic Müller-Glial-Cell-Specific Il6ra Knockout Mice Exhibit Accelerated Retinal Functional Decline and Thinning of the Inner Nuclear Layer
por: Glass, Joshua, et al.
Publicado: (2023)

Involvement of a Basic Helix-Loop-Helix Gene BHLHE40 in Specification of Chicken Retinal Pigment Epithelium
por: Kinuhata, Toshiki, et al.
Publicado: (2022)

Retinal Cone Mosaic in sws1-Mutant Medaka (Oryzias latipes), A Teleost
por: Matsuo, Megumi, et al.
Publicado: (2022)

Effect of rhegmatogenous retinal detachment on preoperative and postoperative retinal sensitivities
por: Noda, Hiroshi, et al.
Publicado: (2020)

Setting Eyes on the Retinal Pigment Epithelium
por: Moreno-Marmol, Tania, et al.
Publicado: (2018)

Prospective PED-study of intravitreal aflibercept for refractory vascularized pigment epithelium detachment due to age-related macular degeneration: morphologic characteristics of non-responders in optical coherence tomography
por: Clemens, C. R., et al.
Publicado: (2020)

Low-Intensity Exercise in Mice Is Sufficient to Protect Retinal Function During Light-Induced Retinal Degeneration
por: Mees, Lukas M., et al.
Publicado: (2019)

Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model
por: Pilgrim, Matthew G., et al.
Publicado: (2017)

Localization of the ultraviolet-sensor Opn5m and its effect on myopia-related gene expression in the late-embryonic chick eye
por: Kato, Mutsuko, et al.
Publicado: (2019)

Compound 49b Regulates ZO-1 and Occludin Levels in Human Retinal Endothelial Cells and in Mouse Retinal Vasculature
por: Jiang, Youde, et al.
Publicado: (2017)

Expression Profiling Analysis Reveals Key MicroRNA–mRNA Interactions in Early Retinal Degeneration in Retinitis Pigmentosa
por: Anasagasti, Ander, et al.
Publicado: (2018)

COMP-Ang1 Stabilizes Hyperglycemic Disruption of Blood-Retinal Barrier Phenotype in Human Retinal Microvascular Endothelial Cells
por: Rochfort, Keith D., et al.
Publicado: (2019)

Acute and Protracted Cell Death in Light-Induced Retinal Degeneration in the Canine Model of Rhodopsin Autosomal Dominant Retinitis Pigmentosa
por: Sudharsan, Raghavi, et al.
Publicado: (2017)

Granulin 1 Promotes Retinal Regeneration in Zebrafish
por: Tsuruma, Kazuhiro, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_7a5fe2bs81fmnhe27c65n7pgh6