Cargando…
Varespladib in the Treatment of Snakebite Envenoming: Development History and Preclinical Evidence Supporting Advancement to Clinical Trials in Patients Bitten by Venomous Snakes
The availability of effective, reliably accessible, and affordable treatments for snakebite envenoming is a critical and long unmet medical need. Recently, small, synthetic toxin-specific inhibitors with oral bioavailability used in conjunction with antivenom have been identified as having the poten...
Autores principales: | Lewin, Matthew R., Carter, Rebecca W., Matteo, Isabel A., Samuel, Stephen P., Rao, Sunita, Fry, Bryan G., Bickler, Philip E. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695340/ https://www.ncbi.nlm.nih.gov/pubmed/36422958 http://dx.doi.org/10.3390/toxins14110783 |
Ejemplares similares
-
Exploration of the Inhibitory Potential of Varespladib for Snakebite Envenomation
por: Wang, Yiding, et al.
Publicado: (2018) -
Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation
por: Lewin, Matthew, et al.
Publicado: (2016) -
The BRAVO Clinical Study Protocol: Oral Varespladib for Inhibition of Secretory Phospholipase A2 in the Treatment of Snakebite Envenoming
por: Carter, Rebecca W., et al.
Publicado: (2022) -
Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms
por: Gutiérrez, José María, et al.
Publicado: (2020) -
On the Immediate Treatment of Persons Bitten by Venomous Snakes
por: Fayrer, J.
Publicado: (1871)