The Synthesis and Preclinical Investigation of Lactosamine-Based Radiopharmaceuticals for the Detection of Galectin-3-Expressing Melanoma Cells

Given that galectin-3 (Gal-3) is a β-galactoside-binding lectin promoting tumor growth and metastatis, it could be a valuable target for the treatment of Gal-3-expressing neoplasms. An aromatic group introduced to the C-3′ position of lactosamine increased its affinity for Gal-3. Herein, we aimed at...

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Detalles Bibliográficos
Autores principales: Gyuricza, Barbara, Szűcs, Ágnes, Szabó, Judit P., Arató, Viktória, Képes, Zita, Szücs, Dániel, Szikra, Dezső, Trencsényi, György, Fekete, Anikó
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695418/
https://www.ncbi.nlm.nih.gov/pubmed/36432695
http://dx.doi.org/10.3390/pharmaceutics14112504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695418/
https://www.ncbi.nlm.nih.gov/pubmed/36432695
http://dx.doi.org/10.3390/pharmaceutics14112504

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