N-Terminally Lipidated Sialorphin Analogs—Synthesis, Molecular Modeling, In Vitro Effect on Enkephalins Degradation by NEP and Treatment of Intestinal Inflammation in Mice

Pharmacotherapy for inflammatory bowel disease (IBD) is difficult, and some patients do not respond to currently available treatments. Therefore, the discovery of novel anti-IBD agents is imperative. Our aim was the synthesis of lipidated analogs of sialorphin and the in vitro characterization of th...

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Detalles Bibliográficos
Autores principales: Sobocińska, Małgorzata, Fichna, Jakub, Giełdoń, Artur, Skowron, Piotr, Kamysz, Elżbieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695599/
https://www.ncbi.nlm.nih.gov/pubmed/36430928
http://dx.doi.org/10.3390/ijms232214450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695599/
https://www.ncbi.nlm.nih.gov/pubmed/36430928
http://dx.doi.org/10.3390/ijms232214450

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