Cargando…

Conservation of Importin α Function in Apicomplexans: Ivermectin and GW5074 Target Plasmodium falciparum Importin α and Inhibit Parasite Growth in Culture

Signal-dependent transport into and out of the nucleus mediated by members of the importin (IMP) superfamily of nuclear transporters is critical to the eukaryotic function and a point of therapeutic intervention with the potential to limit disease progression and pathogenic outcomes. Although the ap...

Descripción completa

Detalles Bibliográficos
Autores principales:	Walunj, Sujata B., Wang, Chunxiao, Wagstaff, Kylie M., Patankar, Swati, Jans, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695642/ https://www.ncbi.nlm.nih.gov/pubmed/36430384 http://dx.doi.org/10.3390/ijms232213899

Ejemplares similares

High-Throughput Screening to Identify Inhibitors of Plasmodium falciparum Importin α
por: Walunj, Sujata B., et al.
Publicado: (2022)

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus
por: Wagstaff, Kylie M., et al.
Publicado: (2012)

Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer
por: Yang, Sundy N. Y., et al.
Publicado: (2019)

Nuclear importin α and its physiological importance
por: Miyamoto, Yoichi, et al.
Publicado: (2012)

The structure of importin α and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP–importin α interactions
por: Jung, Hunmin, et al.
Publicado: (2020)

Data on dimer formation between importin α subtypes
por: Miyamoto, Yoichi, et al.
Publicado: (2016)

The Nuclear Transporter Importin 13 Can Regulate Stress-Induced Cell Death through the Clusterin/KU70 Axis
por: Gajewska, Katarzyna A., et al.
Publicado: (2023)

The role of upstream open reading frames in translation regulation in the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii
por: Kaur, Chhaminder, et al.
Publicado: (2021)

Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1
por: Li, Yunlong, et al.
Publicado: (2021)

Importin α: functions as a nuclear transport factor and beyond
por: OKA, Masahiro, et al.
Publicado: (2018)

Differential Behaviours and Preferential Bindings of Influenza Nucleoproteins on Importins-α
por: Donchet, Amélie, et al.
Publicado: (2020)

Tick Importin-α Is Implicated in the Interactome and Regulome of the Cofactor Subolesin
por: Artigas-Jerónimo, Sara, et al.
Publicado: (2021)

Determination of the Functional Domain Organization of the Importin α Nuclear Import Factor
por: Herold, Andrea, et al.
Publicado: (1998)

Drosophila Importin-α2 Is Involved in Synapse, Axon and Muscle Development
por: Mosca, Timothy J., et al.
Publicado: (2010)

Neurospora Importin α Is Required for Normal Heterochromatic Formation and DNA Methylation
por: Klocko, Andrew D., et al.
Publicado: (2015)

Structural Basis for Importin-α Binding of the Human Immunodeficiency Virus Tat
por: Smith, K. M., et al.
Publicado: (2017)

Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α
por: Chang, Chih-Chia, et al.
Publicado: (2019)

Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response
por: Gajewska, K. A., et al.
Publicado: (2021)

Importins and exportins in cellular differentiation
por: Okada, Norihisa, et al.
Publicado: (2008)

Importin-β facilitates nuclear import of human GW proteins and balances cytoplasmic gene silencing protein levels
por: Schraivogel, Daniel, et al.
Publicado: (2015)

Xenopus importin beta validates human importin beta as a cell cycle negative regulator
por: Delmar, Valerie A, et al.
Publicado: (2008)

The adapter importin-α provides flexible control of nuclear import at the expense of efficiency
por: Riddick, Greg, et al.
Publicado: (2007)

A systems analysis of importin-α–β mediated nuclear protein import
por: Riddick, Gregory, et al.
Publicado: (2005)

Importin α7 Is Essential for Zygotic Genome Activation and Early Mouse Development
por: Rother, Franziska, et al.
Publicado: (2011)

Structural analysis of the complex between influenza B nucleoprotein and human importin-α
por: Labaronne, Alice, et al.
Publicado: (2017)

Differential recognition of canonical NF-κB dimers by Importin α3
por: Florio, Tyler J., et al.
Publicado: (2022)

Recognition of the TDP-43 nuclear localization signal by importin α1/β
por: Doll, Steven G., et al.
Publicado: (2022)

Human Enzyme PADI4 Binds to the Nuclear Carrier Importin α3
por: Neira, José L., et al.
Publicado: (2022)

Acetylation of the nuclear localization signal in Ku70 diminishes the interaction with importin-α
por: Fujimoto, Hirofumi, et al.
Publicado: (2022)

GW5074 Increases Microglial Phagocytic Activities: Potential Therapeutic Direction for Alzheimer’s Disease
por: Connor, Sarah M., et al.
Publicado: (2022)

Nuclear Trafficking of the Rabies Virus Interferon Antagonist P-Protein Is Regulated by an Importin-Binding Nuclear Localization Sequence in the C-Terminal Domain
por: Rowe, Caitlin L., et al.
Publicado: (2016)

Importin α5 negatively regulates importin β1-mediated nuclear import of Newcastle disease virus matrix protein and viral replication and pathogenicity in chicken fibroblasts
por: Duan, Zhiqiang, et al.
Publicado: (2018)

The molecular basis for the regulation of the CBC by the importins
por: Dias, Sandra M.G., et al.
Publicado: (2009)

Development of a pipeline for automated, high-throughput analysis of paraspeckle proteins reveals specific roles for importin α proteins
por: Major, Andrew T., et al.
Publicado: (2017)

Mitotic spindle scaling during Xenopus development by kif2a and importin α
por: Wilbur, Jeremy D, et al.
Publicado: (2013)

Design Rules for Selective Binding of Nuclear Localization Signals to Minor Site of Importin α
por: Pang, Xiaodong, et al.
Publicado: (2014)

Hop-on hop-off: importin-α-guided tours to the nucleus in innate immune signaling
por: Wirthmueller, Lennart, et al.
Publicado: (2013)

Drosophila TIM Binds Importin α1, and Acts as an Adapter to Transport PER to the Nucleus
por: Jang, A. Reum, et al.
Publicado: (2015)

Karyopherin α7 (KPNA7), a divergent member of the importin α family of nuclear import receptors
por: Kelley, Joshua B, et al.
Publicado: (2010)

Specific interaction with the nuclear transporter importin α2 can modulate paraspeckle protein 1 delivery to nuclear paraspeckles
por: Major, Andrew T., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_lt80ub3talufb59n03tklnc1qc