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Plasma p‐tau181/Aβ(1‐42) ratio predicts Aβ‐PET status and correlates with CSF‐p‐tau181/Aβ(1‐42) and future cognitive decline

BACKGROUND: In Alzheimer's disease (AD), plasma amyloid beta (Aβ)(1‐42) and phosphorylated tau (p‐tau) predict high amyloid status from Aβ positron emission tomography (PET); however, the extent to which combination of these plasma assays can predict remains unknown. METHODS: Prototype Simoa as...

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Detalles Bibliográficos
Autores principales: Fowler, Christopher J., Stoops, Erik, Rainey‐Smith, Stephanie R., Vanmechelen, Eugeen, Vanbrabant, Jeroen, Dewit, Nele, Mauroo, Kimberley, Maruff, Paul, Rowe, Christopher C., Fripp, Jurgen, Li, Qiao‐Xin, Bourgeat, Pierrick, Collins, Steven J., Martins, Ralph N., Masters, Colin L., Doecke, James D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695763/
https://www.ncbi.nlm.nih.gov/pubmed/36447478
http://dx.doi.org/10.1002/dad2.12375