The Impact of P-Glycoprotein on Opioid Analgesics: What’s the Real Meaning in Pain Management and Palliative Care?

Opioids are widely used in cancer and non-cancer pain management. However, many transporters at the blood–brain barrier (BBB), such as P-glycoprotein (P-gp, ABCB1/MDR1), may impair their delivery to the brain, thus leading to opioid tolerance. Nonetheless, opioids may regulate P-gp expression, thus...

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Detalles Bibliográficos
Autores principales: Coluzzi, Flaminia, Scerpa, Maria Sole, Rocco, Monica, Fornasari, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695906/
https://www.ncbi.nlm.nih.gov/pubmed/36430602
http://dx.doi.org/10.3390/ijms232214125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695906/
https://www.ncbi.nlm.nih.gov/pubmed/36430602
http://dx.doi.org/10.3390/ijms232214125

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