Deglycosylation Increases the Aggregation and Angiogenic Properties of Mutant Tissue Inhibitor of Metalloproteinase 3 Protein: Implications for Sorsby Fundus Dystrophy

Sorsby fundus dystrophy (SFD) is an autosomal dominant macular disorder caused by mutations in tissue Inhibitor of the metalloproteinase-3 (TIMP3) gene with the onset of symptoms including choroidal neovascularization as early as the second decade of life. We have previously reported that wild-type...

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Detalles Bibliográficos
Autores principales: Qi, Jian Hua, Anand-Apte, Bela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696176/
https://www.ncbi.nlm.nih.gov/pubmed/36430707
http://dx.doi.org/10.3390/ijms232214231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696176/
https://www.ncbi.nlm.nih.gov/pubmed/36430707
http://dx.doi.org/10.3390/ijms232214231

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