Enhancement of Anti-Tumoral Properties of Paclitaxel Nano-Crystals by Conjugation of Folic Acid to Pluronic F127: Formulation Optimization, In Vitro and In Vivo Study

A brand-new nano-crystal (NC) version of the hydrophobic drug Paclitaxel (PT) were formulated for cancer treatment. A stable NC formulation for the administration of PT was created using the triblock co-polymer Pluronic F127. To achieve maximum entrapment effectiveness and minimal particle size, the...

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Detalles Bibliográficos
Autores principales: Sreeharsha, Nagaraja, Prasanthi, Samathoti, Mahalakshmi, Satyavarapu Veera Venkata Naga Satya, Goudanavar, Prakash S., Naveen, Nimbagal Raghavendra, Gowthami, Buduru, Fattepur, Santosh, Meravanige, Girish, Asdaq, Syed Mohammed Basheeruddin, Anwer, Md. Khalid, Aldhubiab, Bandar, Islam, Mohammed Monirul, Habeebuddin, Mohammed, Telsang, Mallikarjun, Gharsan, Mazen Al, Haroun, Michelyne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696646/
https://www.ncbi.nlm.nih.gov/pubmed/36432014
http://dx.doi.org/10.3390/molecules27227914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696646/
https://www.ncbi.nlm.nih.gov/pubmed/36432014
http://dx.doi.org/10.3390/molecules27227914

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