Synthesis and Antimicrobial Activity of Short Analogues of the Marine Antimicrobial Peptide Turgencin A: Effects of SAR Optimizations, Cys-Cys Cyclization and Lipopeptide Modifications

We have synthesised short analogues of the marine antimicrobial peptide Turgencin A from the colonial Arctic ascidian Synoicum turgens. In this study, we focused on a central, cationic 12-residue Cys-Cys loop region within the sequence. Modified (tryptophan- and arginine-enriched) linear peptides we...

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Detalles Bibliográficos
Autores principales: Dey, Hymonti, Simonovic, Danijela, Norberg-Schulz Hagen, Ingrid, Vasskog, Terje, Fredheim, Elizabeth G. Aarag, Blencke, Hans-Matti, Anderssen, Trude, Strøm, Morten B., Haug, Tor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696794/
https://www.ncbi.nlm.nih.gov/pubmed/36430320
http://dx.doi.org/10.3390/ijms232213844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696794/
https://www.ncbi.nlm.nih.gov/pubmed/36430320
http://dx.doi.org/10.3390/ijms232213844

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