Pyrazole-Based Thrombin Inhibitors with a Serine-Trapping Mechanism of Action: Synthesis and Biological Activity

New antithrombotic drugs are needed to combat thrombosis, a dangerous pathology that causes myocardial infarction and ischemic stroke. In this respect, thrombin (FIIa) represents an important drug target. We herein report the synthesis and biological activity of a series of 1H-pyrazol-5-amine-based...

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Detalles Bibliográficos
Autores principales: Dunker, Calvin, Imberg, Lukas, Siutkina, Alena I., Erbacher, Catharina, Daniliuc, Constantin G., Karst, Uwe, Kalinin, Dmitrii V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696832/
https://www.ncbi.nlm.nih.gov/pubmed/36355511
http://dx.doi.org/10.3390/ph15111340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696832/
https://www.ncbi.nlm.nih.gov/pubmed/36355511
http://dx.doi.org/10.3390/ph15111340

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