Identification of Novel Diarylpyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors by Exploring the Primer Grip Region

HIV-1 reverse transcriptase (RT) plays a crucial role in the viral replication cycle, and RT inhibitors can represent a promising pathway in treating AIDS. To explore the primer grip region of HIV-1 RT, using -CH(2)O- as a linker, substituted benzene or pyridine rings were introduced into the left w...

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Detalles Bibliográficos
Autores principales: Zhang, Tao, Zhou, Zhongxia, Zhao, Fabao, Sang, Zihao, De Clercq, Erik, Pannecouque, Christophe, Kang, Dongwei, Zhan, Peng, Liu, Xinyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697031/
https://www.ncbi.nlm.nih.gov/pubmed/36422568
http://dx.doi.org/10.3390/ph15111438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697031/
https://www.ncbi.nlm.nih.gov/pubmed/36422568
http://dx.doi.org/10.3390/ph15111438

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