The Impacts of Iron Overload and Ferroptosis on Intestinal Mucosal Homeostasis and Inflammation

Intestinal homeostasis is maintained through the interplay of the intestinal mucosa, local and systemic immune factors, and the microbial content of the gut. Iron is a trace mineral in most organisms, including humans, which is essential for growth, systemic metabolism and immune response. Paradoxic...

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Autores principales: Huo, Caiyun, Li, Guiping, Hu, Yanxin, Sun, Huiling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697168/
https://www.ncbi.nlm.nih.gov/pubmed/36430673
http://dx.doi.org/10.3390/ijms232214195
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author Huo, Caiyun
Li, Guiping
Hu, Yanxin
Sun, Huiling
author_facet Huo, Caiyun
Li, Guiping
Hu, Yanxin
Sun, Huiling
author_sort Huo, Caiyun
collection PubMed
description Intestinal homeostasis is maintained through the interplay of the intestinal mucosa, local and systemic immune factors, and the microbial content of the gut. Iron is a trace mineral in most organisms, including humans, which is essential for growth, systemic metabolism and immune response. Paradoxically, excessive iron intake and/or high iron status can be detrimental to iron metabolism in the intestine and lead to iron overload and ferroptosis-programmed cell death mediated by iron-dependent lipid peroxidation within cell membranes, which contributes to several intestinal diseases. In this review, we comprehensively review recent findings on the impacts of iron overload and ferroptosis on intestinal mucosal homeostasis and inflammation and then present the progress of iron overload and ferroptosis-targeting therapy in intestinal diseases. Understanding the involved mechanisms can provide a new understanding of intestinal disease pathogenesis and facilitate advanced preventive and therapeutic strategies for intestinal dysfunction and diseases.
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spelling pubmed-96971682022-11-26 The Impacts of Iron Overload and Ferroptosis on Intestinal Mucosal Homeostasis and Inflammation Huo, Caiyun Li, Guiping Hu, Yanxin Sun, Huiling Int J Mol Sci Review Intestinal homeostasis is maintained through the interplay of the intestinal mucosa, local and systemic immune factors, and the microbial content of the gut. Iron is a trace mineral in most organisms, including humans, which is essential for growth, systemic metabolism and immune response. Paradoxically, excessive iron intake and/or high iron status can be detrimental to iron metabolism in the intestine and lead to iron overload and ferroptosis-programmed cell death mediated by iron-dependent lipid peroxidation within cell membranes, which contributes to several intestinal diseases. In this review, we comprehensively review recent findings on the impacts of iron overload and ferroptosis on intestinal mucosal homeostasis and inflammation and then present the progress of iron overload and ferroptosis-targeting therapy in intestinal diseases. Understanding the involved mechanisms can provide a new understanding of intestinal disease pathogenesis and facilitate advanced preventive and therapeutic strategies for intestinal dysfunction and diseases. MDPI 2022-11-17 /pmc/articles/PMC9697168/ /pubmed/36430673 http://dx.doi.org/10.3390/ijms232214195 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Huo, Caiyun
Li, Guiping
Hu, Yanxin
Sun, Huiling
The Impacts of Iron Overload and Ferroptosis on Intestinal Mucosal Homeostasis and Inflammation
title The Impacts of Iron Overload and Ferroptosis on Intestinal Mucosal Homeostasis and Inflammation
title_full The Impacts of Iron Overload and Ferroptosis on Intestinal Mucosal Homeostasis and Inflammation
title_fullStr The Impacts of Iron Overload and Ferroptosis on Intestinal Mucosal Homeostasis and Inflammation
title_full_unstemmed The Impacts of Iron Overload and Ferroptosis on Intestinal Mucosal Homeostasis and Inflammation
title_short The Impacts of Iron Overload and Ferroptosis on Intestinal Mucosal Homeostasis and Inflammation
title_sort impacts of iron overload and ferroptosis on intestinal mucosal homeostasis and inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697168/
https://www.ncbi.nlm.nih.gov/pubmed/36430673
http://dx.doi.org/10.3390/ijms232214195
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