GADD34 Ablation Exacerbates Retinal Degeneration in P23H RHO Mice

The UPR is sustainably activated in degenerating retinas, leading to translational inhibition via p-eIF2α. Recent findings have demonstrated that ablation of growth arrest and DNA damage-inducible protein 34 (GADD34), a protein phosphatase 1 regulatory subunit permitting translational machinery oper...

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Detalles Bibliográficos
Autores principales: Saltykova, Irina V., Zhylkibayev, Assylbek, Gorbatyuk, Oleg S., Gorbatyuk, Marina S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697375/
https://www.ncbi.nlm.nih.gov/pubmed/36430227
http://dx.doi.org/10.3390/ijms232213748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697375/
https://www.ncbi.nlm.nih.gov/pubmed/36430227
http://dx.doi.org/10.3390/ijms232213748

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