Evaluation of Pharmacological Rescue of Melanocortin-4 Receptor Nonsense Mutations by Aminoglycoside

The melanocortin-4 receptor (MC4R) is critical for central satiety regulation, therefore presenting a potent target for pharmacological obesity treatment. Melanocortin-4 receptor mutations prevalently cause monogenetic obesity. A possibility of overcoming stop mutations is aminoglycoside-mediated tr...

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Detalles Bibliográficos
Autores principales: Höpfner, Friederike, Paisdzior, Sarah, Reininghaus, Nanina, Sohail, Iqra, Scheerer, Patrick, Annibale, Paolo, Biebermann, Heike, Kühnen, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697516/
https://www.ncbi.nlm.nih.gov/pubmed/36362948
http://dx.doi.org/10.3390/life12111793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697516/
https://www.ncbi.nlm.nih.gov/pubmed/36362948
http://dx.doi.org/10.3390/life12111793

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