Cargando…

Evaluation of Pharmacological Rescue of Melanocortin-4 Receptor Nonsense Mutations by Aminoglycoside

The melanocortin-4 receptor (MC4R) is critical for central satiety regulation, therefore presenting a potent target for pharmacological obesity treatment. Melanocortin-4 receptor mutations prevalently cause monogenetic obesity. A possibility of overcoming stop mutations is aminoglycoside-mediated tr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Höpfner, Friederike, Paisdzior, Sarah, Reininghaus, Nanina, Sohail, Iqra, Scheerer, Patrick, Annibale, Paolo, Biebermann, Heike, Kühnen, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697516/ https://www.ncbi.nlm.nih.gov/pubmed/36362948 http://dx.doi.org/10.3390/life12111793

Ejemplares similares

A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation
por: Reininghaus, Nanina, et al.
Publicado: (2022)

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands
por: Paisdzior, Sarah, et al.
Publicado: (2020)

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective
por: Heyder, Nicolas, et al.
Publicado: (2019)

Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide
por: Heyder, Nicolas A., et al.
Publicado: (2021)

Aminoglycosides, but not PTC124 (Ataluren), rescue nonsense mutations in the leptin receptor and in luciferase reporter genes
por: Bolze, Florian, et al.
Publicado: (2017)

Functional Restoration of BRCA1 Nonsense Mutations by Aminoglycoside-Induced Readthrough
por: Abreu, Renata B. V., et al.
Publicado: (2022)

Functional characterization and pharmacological rescue of melanocortin-4 receptor mutations identified from obese patients
por: Fan, Zhen-Chuan, et al.
Publicado: (2009)

Balancing Nonsense Mutation Readthrough and Toxicity of Designer Aminoglycosides for Treatment of Genetic Diseases
por: Guchhait, Sandip, et al.
Publicado: (2023)

Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors
por: Zhang, Meiqiongzi, et al.
Publicado: (2018)

The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor
por: Bräunig, Julia, et al.
Publicado: (2018)

Rescue of nonsense mutations by amlexanox in human cells
por: Gonzalez-Hilarion, Sara, et al.
Publicado: (2012)

Recoding of Nonsense Mutation as a Pharmacological Strategy
por: Temaj, Gazmend, et al.
Publicado: (2023)

Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model
por: Brendel, Cornelia, et al.
Publicado: (2010)

Ataluren and aminoglycosides stimulate read-through of nonsense codons by orthogonal mechanisms
por: Ng, Martin Y., et al.
Publicado: (2021)

Melanocortin Receptor Accessory Protein 2-Induced Adrenocorticotropic Hormone Response of Human Melanocortin 4 Receptor
por: Soletto, Lucia, et al.
Publicado: (2018)

Erratum to: Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model
por: Brendel, Cornelia, et al.
Publicado: (2013)

A New Mechanism in THRA Resistance: The First Disease-Associated Variant Leading to an Increased Inhibitory Function of THRA2
por: Paisdzior, Sarah, et al.
Publicado: (2021)

SAT026 Melanocortin Receptors In The Earliest Chordates?
por: Ji, Ren-Lei, et al.
Publicado: (2023)

Rescue of non-sense mutated p53 tumor suppressor gene by aminoglycosides
por: Floquet, Célia, et al.
Publicado: (2011)

CRISPR-Pass: Gene Rescue of Nonsense Mutations Using Adenine Base Editors
por: Lee, Choongil, et al.
Publicado: (2019)

Structural Complexity and Plasticity of Signaling Regulation at the Melanocortin-4 Receptor
por: Kleinau, Gunnar, et al.
Publicado: (2020)

Comprehensive Analysis of Combinatorial Pharmacological Treatments to Correct Nonsense Mutations in the CFTR Gene
por: Venturini, Arianna, et al.
Publicado: (2021)

Pharmacological Evaluation of Melanocortin 2 Receptor Accessory Protein 2 on Axolotl Neural Melanocortin Signaling
por: Wang, Xiaozhu, et al.
Publicado: (2022)

Ring Finger Protein 11 Inhibits Melanocortin 3 and 4 Receptor Signaling
por: Müller, Anne, et al.
Publicado: (2016)

Insights into Basal Signaling Regulation, Oligomerization, and Structural Organization of the Human G-Protein Coupled Receptor 83
por: Müller, Anne, et al.
Publicado: (2016)

Learning pharmacology by metaphors: A tale of aminoglycosides
por: Khilnani, Gurudas, et al.
Publicado: (2016)

Demonstration of a Common DPhe(7) to DNal(2′)(7) Peptide Ligand Antagonist Switch for Melanocortin-3 and Melanocortin-4 Receptors Identifies the Systematic Mischaracterization of the Pharmacological Properties of Melanocortin Peptides
por: Gimenez, Luis E., et al.
Publicado: (2022)

Binding, Thermodynamics, and Selectivity of a Non-peptide Antagonist to the Melanocortin-4 Receptor
por: Saleh, Noureldin, et al.
Publicado: (2018)

Pharmacological induction of translational readthrough of nonsense mutations in the retinoblastoma (RB1) gene
por: Palomar-Siles, Mireia, et al.
Publicado: (2023)

Investigation of a Genome Wide Association Signal for Obesity: Synthetic Association and Haplotype Analyses at the Melanocortin 4 Receptor Gene Locus
por: Scherag, André, et al.
Publicado: (2010)

Melanocortins, Melanocortin Receptors and Multiple Sclerosis
por: Lisak, Robert P., et al.
Publicado: (2017)

Melanocortin-5 Receptor: Pharmacology and Its Regulation of Energy Metabolism
por: Ji, Li-Qin, et al.
Publicado: (2022)

Regulation of Melanocortin-4 Receptor Pharmacology by Two Isoforms of Melanocortin Receptor Accessory Protein 2 in Topmouth Culter (Culter alburnus)
por: Tao, Min, et al.
Publicado: (2020)

Missense and nonsense mutations in melanocortin 1 receptor (MC1R) gene of different goat breeds: association with red and black coat colour phenotypes but with unexpected evidences
por: Fontanesi, Luca, et al.
Publicado: (2009)

Ex Vivo Treatment with a Novel Synthetic Aminoglycoside NB54 in Primary Fibroblasts from Rett Syndrome Patients Suppresses MECP2 Nonsense Mutations
por: Vecsler, Manuela, et al.
Publicado: (2011)

Stop codons and the +4 nucleotide may influence the efficiency of G418 in rescuing nonsense mutations of the HERG gene
por: Yu, Haiyun, et al.
Publicado: (2019)

Pharmacological modulation of the cAMP signaling of two isoforms of melanocortin-3 receptor by melanocortin receptor accessory proteins in the tetrapod Xenopus laevis
por: Xu, Ying, et al.
Publicado: (2021)

Pharmacological modulation of MRAP2 protein on melanocortin receptors in the sea lamprey
por: Zhu, Ming, et al.
Publicado: (2019)

Melanocortin 1 Receptor (MC1R): Pharmacological and Therapeutic Aspects
por: Mun, Yoonwoo, et al.
Publicado: (2023)

Pharmacological read-through of nonsense ARSB mutations as a potential therapeutic approach for mucopolysaccharidosis VI
por: Bartolomeo, Rosa, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_nbmc3svqe564ofcvfk6kvsvfie