Rufinamide, a Triazole-Derived Antiepileptic Drug, Stimulates Ca(2+)-Activated K(+) Currents While Inhibiting Voltage-Gated Na(+) Currents

Rufinamide (RFM) is a clinically utilized antiepileptic drug that, as a triazole derivative, has a unique structure. The extent to which this drug affects membrane ionic currents remains incompletely understood. With the aid of patch clamp technology, we investigated the effects of RFM on the amplit...

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Detalles Bibliográficos
Autores principales: Lai, Ming-Chi, Wu, Sheng-Nan, Huang, Chin-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697614/
https://www.ncbi.nlm.nih.gov/pubmed/36430153
http://dx.doi.org/10.3390/ijms232213677

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697614/
https://www.ncbi.nlm.nih.gov/pubmed/36430153
http://dx.doi.org/10.3390/ijms232213677

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