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Rufinamide, a Triazole-Derived Antiepileptic Drug, Stimulates Ca(2+)-Activated K(+) Currents While Inhibiting Voltage-Gated Na(+) Currents
Rufinamide (RFM) is a clinically utilized antiepileptic drug that, as a triazole derivative, has a unique structure. The extent to which this drug affects membrane ionic currents remains incompletely understood. With the aid of patch clamp technology, we investigated the effects of RFM on the amplit...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697614/ https://www.ncbi.nlm.nih.gov/pubmed/36430153 http://dx.doi.org/10.3390/ijms232213677 |