(E)-N-(3-(1-(2-(4-(2,2,2-Trifluoroacetamido)benzoyl)hydrazono)ethyl)phenyl)nicotinamide: A Novel Pyridine Derivative for Inhibiting Vascular Endothelial Growth Factor Receptor-2: Synthesis, Computational, and Anticancer Studies

(E)-N-(3-(1-(2-(4-(2,2,2-Trifluoroacetamido)benzoyl)hydrazono)ethyl)phenyl)nicotinamide (compound 10) was designed as an antiangiogenic VEGFR-2 inhibitor with the essential pharmacophoric structural properties to interact with the catalytic pocket of VEGFR-2. The designed derivative was synthesized,...

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Detalles Bibliográficos
Autores principales: Yousef, Reda G., Elkady, Hazem, Elkaeed, Eslam B., Gobaara, Ibraheem M. M., Al-ghulikah, Hanan A., Husein, Dalal Z., Ibrahim, Ibrahim M., Metwaly, Ahmed M., Eissa, Ibrahim H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697799/
https://www.ncbi.nlm.nih.gov/pubmed/36431818
http://dx.doi.org/10.3390/molecules27227719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697799/
https://www.ncbi.nlm.nih.gov/pubmed/36431818
http://dx.doi.org/10.3390/molecules27227719

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