BmooMPα-I, a Metalloproteinase Isolated from Bothrops moojeni Venom, Reduces Blood Pressure, Reverses Left Ventricular Remodeling and Improves Cardiac Electrical Conduction in Rats with Renovascular Hypertension

BmooMPα-I has kininogenase activity, cleaving kininogen releasing bradykinin and can hydrolyze angiotensin I at post-proline and aspartic acid positions, generating an inactive peptide. We evaluated the antihypertensive activity of BmooMPα-I in a model of two-kidney, one-clip (2K1C). Wistar rats wer...

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Detalles Bibliográficos
Autores principales: Estrada, Jorge Eduardo Chang, Rodrigues, Keuri Eleutério, Maciel, Anderson, Bannwart, Cahy Manoel, Dias, Wictória Farias, Hamoy, Moisés, Zingali, Russolina Benedeta, Soares, Andreimar Martins, Ribeiro, Carolina Heitmann Mares Azevedo, Gerlach, Raquel Fernanda, Monteiro, Marta Chagas, Prado, Alejandro Ferraz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697896/
https://www.ncbi.nlm.nih.gov/pubmed/36356016
http://dx.doi.org/10.3390/toxins14110766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697896/
https://www.ncbi.nlm.nih.gov/pubmed/36356016
http://dx.doi.org/10.3390/toxins14110766

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