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BmooMPα-I, a Metalloproteinase Isolated from Bothrops moojeni Venom, Reduces Blood Pressure, Reverses Left Ventricular Remodeling and Improves Cardiac Electrical Conduction in Rats with Renovascular Hypertension
BmooMPα-I has kininogenase activity, cleaving kininogen releasing bradykinin and can hydrolyze angiotensin I at post-proline and aspartic acid positions, generating an inactive peptide. We evaluated the antihypertensive activity of BmooMPα-I in a model of two-kidney, one-clip (2K1C). Wistar rats wer...
Autores principales: | Estrada, Jorge Eduardo Chang, Rodrigues, Keuri Eleutério, Maciel, Anderson, Bannwart, Cahy Manoel, Dias, Wictória Farias, Hamoy, Moisés, Zingali, Russolina Benedeta, Soares, Andreimar Martins, Ribeiro, Carolina Heitmann Mares Azevedo, Gerlach, Raquel Fernanda, Monteiro, Marta Chagas, Prado, Alejandro Ferraz |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697896/ https://www.ncbi.nlm.nih.gov/pubmed/36356016 http://dx.doi.org/10.3390/toxins14110766 |
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