Drug Combination Studies of the Dipeptide Nitrile CD24 with Curcumin: A New Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense

Rhodesain is a cysteine protease that is crucial for the life cycle of Trypanosoma brucei rhodesiense, a parasite causing the lethal form of Human African Trypanosomiasis. CD24 is a recently developed synthetic inhibitor of rhodesain, characterized by a nanomolar affinity towards the trypanosomal pr...

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Detalles Bibliográficos
Autores principales: Di Chio, Carla, Previti, Santo, De Luca, Fabiola, Bogacz, Marta, Zimmer, Collin, Wagner, Annika, Schirmeister, Tanja, Zappalà, Maria, Ettari, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698140/
https://www.ncbi.nlm.nih.gov/pubmed/36430948
http://dx.doi.org/10.3390/ijms232214470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698140/
https://www.ncbi.nlm.nih.gov/pubmed/36430948
http://dx.doi.org/10.3390/ijms232214470

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