Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design

The field of targeted protein degradation, through the control of the ubiquitin–proteasome system (UPS), is progressing considerably; to exploit this new therapeutic modality, the proteolysis targeting chimera (PROTAC) technology was born. The opportunity to use PROTACs engaging of new E3 ligases th...

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Detalles Bibliográficos
Autores principales: Palomba, Tommaso, Tassone, Giusy, Vacca, Carmine, Bartalucci, Matteo, Valeri, Aurora, Pozzi, Cecilia, Cross, Simon, Siragusa, Lydia, Desantis, Jenny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698485/
https://www.ncbi.nlm.nih.gov/pubmed/36430693
http://dx.doi.org/10.3390/ijms232214218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698485/
https://www.ncbi.nlm.nih.gov/pubmed/36430693
http://dx.doi.org/10.3390/ijms232214218

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