Cargando…

Impact of Daily Consumption of Whole-Grain Quinoa-Enriched Bread on Gut Microbiome in Males

Diets rich in whole grains are associated with improved health and a lower risk of non-communicable diseases, but the mechanisms through which these health benefits are conveyed are uncertain. One mechanism may be improvements in the gut environment by the delivery of fermentable substrates and asso...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Liangkui, Houghton, David, Lietz, Georg, Watson, Anthony, Stewart, Christopher J., Bal, Wendy, Seal, Chris J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698549/
https://www.ncbi.nlm.nih.gov/pubmed/36432574
http://dx.doi.org/10.3390/nu14224888
_version_ 1784838847142559744
author Li, Liangkui
Houghton, David
Lietz, Georg
Watson, Anthony
Stewart, Christopher J.
Bal, Wendy
Seal, Chris J.
author_facet Li, Liangkui
Houghton, David
Lietz, Georg
Watson, Anthony
Stewart, Christopher J.
Bal, Wendy
Seal, Chris J.
author_sort Li, Liangkui
collection PubMed
description Diets rich in whole grains are associated with improved health and a lower risk of non-communicable diseases, but the mechanisms through which these health benefits are conveyed are uncertain. One mechanism may be improvements in the gut environment by the delivery of fermentable substrates and associated phytochemicals to the lower gut and modification of the gut microbiome. Quinoa is included in the whole-grain category because of its structural similarities to cereals but the effects of its consumption on the gut microbiome have not been investigated to date. Our aim was to examine the impact of daily quinoa consumption on the gut microbiome in a 4-week randomised cross-over intervention separated by a 4-week wash-out period involving 28 adult males. Participants consumed either a quinoa-enriched wheat-bread roll providing 20 g quinoa flour each day, or a control wheat-only bread roll. Stool samples were collected in sterile collection tubes immediately before and at the end of each intervention period. DNA was then extracted, and the 16S rRNA V4 region of extracted DNA was amplified and sequenced. For both the control and quinoa bread periods, there were no changes at the phyla or genus level between baseline and week 4 (all p > 0.05). Diversity in the microbiome profile was not different from baseline after either intervention arms. The results show that small changes in the type of cereal consumed—substituting 20 g of refined wheat flour with whole-grain quinoa flour—was not able to significantly modulate the gut microbiome. Further studies with higher levels of quinoa or longer exposure periods are needed to ascertain if there is a dose–response effect of quinoa, and if these effects are able to translate into clinical outcomes.
format Online
Article
Text
id pubmed-9698549
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96985492022-11-26 Impact of Daily Consumption of Whole-Grain Quinoa-Enriched Bread on Gut Microbiome in Males Li, Liangkui Houghton, David Lietz, Georg Watson, Anthony Stewart, Christopher J. Bal, Wendy Seal, Chris J. Nutrients Article Diets rich in whole grains are associated with improved health and a lower risk of non-communicable diseases, but the mechanisms through which these health benefits are conveyed are uncertain. One mechanism may be improvements in the gut environment by the delivery of fermentable substrates and associated phytochemicals to the lower gut and modification of the gut microbiome. Quinoa is included in the whole-grain category because of its structural similarities to cereals but the effects of its consumption on the gut microbiome have not been investigated to date. Our aim was to examine the impact of daily quinoa consumption on the gut microbiome in a 4-week randomised cross-over intervention separated by a 4-week wash-out period involving 28 adult males. Participants consumed either a quinoa-enriched wheat-bread roll providing 20 g quinoa flour each day, or a control wheat-only bread roll. Stool samples were collected in sterile collection tubes immediately before and at the end of each intervention period. DNA was then extracted, and the 16S rRNA V4 region of extracted DNA was amplified and sequenced. For both the control and quinoa bread periods, there were no changes at the phyla or genus level between baseline and week 4 (all p > 0.05). Diversity in the microbiome profile was not different from baseline after either intervention arms. The results show that small changes in the type of cereal consumed—substituting 20 g of refined wheat flour with whole-grain quinoa flour—was not able to significantly modulate the gut microbiome. Further studies with higher levels of quinoa or longer exposure periods are needed to ascertain if there is a dose–response effect of quinoa, and if these effects are able to translate into clinical outcomes. MDPI 2022-11-18 /pmc/articles/PMC9698549/ /pubmed/36432574 http://dx.doi.org/10.3390/nu14224888 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Liangkui
Houghton, David
Lietz, Georg
Watson, Anthony
Stewart, Christopher J.
Bal, Wendy
Seal, Chris J.
Impact of Daily Consumption of Whole-Grain Quinoa-Enriched Bread on Gut Microbiome in Males
title Impact of Daily Consumption of Whole-Grain Quinoa-Enriched Bread on Gut Microbiome in Males
title_full Impact of Daily Consumption of Whole-Grain Quinoa-Enriched Bread on Gut Microbiome in Males
title_fullStr Impact of Daily Consumption of Whole-Grain Quinoa-Enriched Bread on Gut Microbiome in Males
title_full_unstemmed Impact of Daily Consumption of Whole-Grain Quinoa-Enriched Bread on Gut Microbiome in Males
title_short Impact of Daily Consumption of Whole-Grain Quinoa-Enriched Bread on Gut Microbiome in Males
title_sort impact of daily consumption of whole-grain quinoa-enriched bread on gut microbiome in males
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698549/
https://www.ncbi.nlm.nih.gov/pubmed/36432574
http://dx.doi.org/10.3390/nu14224888
work_keys_str_mv AT liliangkui impactofdailyconsumptionofwholegrainquinoaenrichedbreadongutmicrobiomeinmales
AT houghtondavid impactofdailyconsumptionofwholegrainquinoaenrichedbreadongutmicrobiomeinmales
AT lietzgeorg impactofdailyconsumptionofwholegrainquinoaenrichedbreadongutmicrobiomeinmales
AT watsonanthony impactofdailyconsumptionofwholegrainquinoaenrichedbreadongutmicrobiomeinmales
AT stewartchristopherj impactofdailyconsumptionofwholegrainquinoaenrichedbreadongutmicrobiomeinmales
AT balwendy impactofdailyconsumptionofwholegrainquinoaenrichedbreadongutmicrobiomeinmales
AT sealchrisj impactofdailyconsumptionofwholegrainquinoaenrichedbreadongutmicrobiomeinmales