Neuropeptides, New Ligands of SARS-CoV-2 Nucleoprotein, a Potential Link between Replication, Inflammation and Neurotransmission

This work identifies new ligands of the nucleoprotein N of SARS-CoV-2 by in silico screening, which used a new model of N, built from an Alphafold model refined by molecular dynamic simulations. The ligands were neuropeptides, such as substance P (1-7) and enkephalin, bound at a large site of the C-...

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Detalles Bibliográficos
Autores principales: Henri, Julien, Minder, Laetitia, Mohanasundaram, Kevin, Dilly, Sébastien, Goupil-Lamy, Anne, Di Primo, Carmelo, Slama Schwok, Anny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698730/
https://www.ncbi.nlm.nih.gov/pubmed/36432196
http://dx.doi.org/10.3390/molecules27228094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698730/
https://www.ncbi.nlm.nih.gov/pubmed/36432196
http://dx.doi.org/10.3390/molecules27228094

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