Design, Synthesis, Molecular Modeling, and Anticancer Evaluation of New VEGFR-2 Inhibitors Based on the Indolin-2-One Scaffold

A new series of indoline-2-one derivatives was designed and synthesized based on the essential pharmacophoric features of VEGFR-2 inhibitors. Anti-proliferative activities were assessed for all derivatives against breast (MCF-7) and liver (HepG2) cancer cell lines, using sunitinib as a reference age...

Descripción completa

Detalles Bibliográficos
Autores principales: Abdelgawad, Mohamed A., Hayallah, Alaa M., Bukhari, Syed Nasir Abbas, Musa, Arafa, Elmowafy, Mohammed, Abdel-Rahman, Hamdy M., Abd El-Gaber, Mohammed K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698773/
https://www.ncbi.nlm.nih.gov/pubmed/36422546
http://dx.doi.org/10.3390/ph15111416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698773/
https://www.ncbi.nlm.nih.gov/pubmed/36422546
http://dx.doi.org/10.3390/ph15111416

Ejemplares similares