Chronic Trazodone and Citalopram Treatments Increase Trophic Factor and Circadian Rhythm Gene Expression in Rat Brain Regions Relevant for Antidepressant Efficacy

Trazodone is an efficacious atypical antidepressant acting both as an SSRI and a 5HT2A and 5HT2C antagonist. Antagonism to H1-histaminergic and alpha1-adrenergic receptors is responsible for a sleep-promoting action. We studied long-term gene expression modulations induced by chronic trazodone to in...

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Detalles Bibliográficos
Autores principales: Carboni, Lucia, Rullo, Laura, Caputi, Francesca Felicia, Stamatakos, Serena, Candeletti, Sanzio, Romualdi, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698904/
https://www.ncbi.nlm.nih.gov/pubmed/36430520
http://dx.doi.org/10.3390/ijms232214041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698904/
https://www.ncbi.nlm.nih.gov/pubmed/36430520
http://dx.doi.org/10.3390/ijms232214041

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